Propofol EC50 for Inducing Loss of Consciousness in General Combined Epidural Anesthesia
Status:
Completed
Trial end date:
2021-11-05
Target enrollment:
Participant gender:
Summary
The beneficial of perioperative usage of thoracic epidural anesthesia and analgesia in
various thoracic and upper abdominal surgery are well studied. However, intraoperative data
are lacking whether combined thoracic epidural and general anesthesia have effect on the
median (50%) effective effect-concentration (EC50) of propofol for inducing loss of
consciousness (LOC). We performed this study among patients undergoing open gastrectomy in
gastric cancer patients.
Forty-eight patients undergoing open gastrectomy were randomly assigned to two groups with
thoracic combined general anesthesia (TEA+GA) or general anesthesia (GA) alone.
Target-controlled infusion (TCI) of propofol was used for anesthesia induction. The initial
propofol concentration of target effect-site (Ceprop) was 3.5 ug/ml and was increased
stepwise by 0.5ug/ml at each 4 min intervals by an un-down sequential method to reach LOC.
The predicted Ceprop at the time of LOC, intravenous anesthetics, vasopressor requirement,
emergency time from anesthesia and postoperative numeric rating scale (NRS) were recorded and
analyzed between two groups.