Propofol EC50 for Inducing Loss of Consciousness in General Combined Epidural Anesthesia

• Status: Completed
• Trial end date: 2021-11-05
• Target enrollment: 0
• Participant gender: All

Summary

The beneficial of perioperative usage of thoracic epidural anesthesia and analgesia in various thoracic and upper abdominal surgery are well studied. However, intraoperative data are lacking whether combined thoracic epidural and general anesthesia have effect on the median (50%) effective effect-concentration (EC50) of propofol for inducing loss of consciousness (LOC). We performed this study among patients undergoing open gastrectomy in gastric cancer patients.

Forty-eight patients undergoing open gastrectomy were randomly assigned to two groups with thoracic combined general anesthesia (TEA+GA) or general anesthesia (GA) alone. Target-controlled infusion (TCI) of propofol was used for anesthesia induction. The initial propofol concentration of target effect-site (Ceprop) was 3.5 ug/ml and was increased stepwise by 0.5ug/ml at each 4 min intervals by an un-down sequential method to reach LOC. The predicted Ceprop at the time of LOC, intravenous anesthetics, vasopressor requirement, emergency time from anesthesia and postoperative numeric rating scale (NRS) were recorded and analyzed between two groups.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: wangjiangling
• Treatments: Ropivacaine

Criteria

Inclusion Criteria:

Gastric cancer patients age between 18-75 yrs;

ASA physical state I and II

Undergoing open gastrectomy

Exclusion Criteria:

With contraindications to epidural puncture or catheter placement

Chronic or acute (within 48 h) intake of psychotropic drugs, benzodiazepines, anticonvulsants, or opioids; alcoholism

Hepatic, renal, neurological or other organ dysfunctiony

Younger than 18 years or older than 75 years

Allergic to local anesthetic solutions or opioids

Received neo-adjuvant chemotherapy

Refuse to receive epidural puncture