Prophylaxis of Acute Post-Traumatic Bacterial Endophthalmitis
Status:
Completed
Trial end date:
2004-12-01
Target enrollment:
Participant gender:
Summary
Purpose: To evaluate the efficacy of combined intraocular injection of gentamycin and
clindamycin in prevention of acute posttraumatic bacterial endophthalmitis (APBE) following
penetrating eye injuries.
Design: Multicenter, randomized, double masked, controlled trial. Participants: Three hundred
forty six eyes of 346 patients with penetrating eye injury.
Method: Following primary repair, eyes were randomized to receive a 0.1 ml intracameral or
intravitreal injection of 40µg gentamycin and 45µg clindamycin (cases), versus intracameral
or intravitreal injection of 0.1ml balanced saline solution (controls). All patients received
standard prophylactic antibiotic therapy (systemic, subconjunctival and topical).
Main outcome measures: Occurrence of endophthalmitis within two weeks after primary repair.