Prophylactic Use of Postpartum Sertraline to Prevent Postpartum Depression

• Status: Terminated
• Trial end date: 2015-07-01
• Target enrollment: 0
• Participant gender: Female

Summary

The purpose of this project is to assess the effectiveness of preventative antidepressants immediately following delivery on postpartum depression rates in women at high risk due to prior history of depression or postpartum depression.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: The Cooper Health System
• Treatments: Sertraline

Criteria

Inclusion Criteria:

1. Past history of depression or postpartum depression

2. Singleton gestation

3. Delivery > 34 weeks gestation

4. No current clinical evidence of depression

5. Able to read and understand written English language

Exclusion Criteria:

1. Multiple gestation

2. Delivery prior to 34 weeks

3. Delivery outside of Cooper University Hospital

4. Major fetal anomaly or fetal demise

5. Current use of antidepressants

6. Evidence of active depression at antepartum evaluation

7. Edinburgh Postpartum Depression scale of >12 prior to discharge from the hospital

8. Maternal age < 18 years

9. Infant in Neonatal Intensive Care Unit (NICU) at time of patient discharge from hospital

10. Known or suspected allergy to Sertraline