Prophylactic Tamsulosin in Prevention of Post-operative Urinary Retention in Men After Transanal Endoscopic Microsurgery
Status:
Recruiting
Trial end date:
2022-10-01
Target enrollment:
Participant gender:
Summary
Post-operative urinary retention (POUR) is a frequent complication reported as ranging from
10 to 55% in the literature. In a recent retrospective study from Laliberte et al in Quebec
City, we observed that 19% of the patients operated using transanal endoscopic microsurgery
(TEM) had a post-operative urinary retention (POUR). Factors related to the patient, the
tumor and the surgery were not observed to be associated risk factors. Tamsulosin has been
shown as an effective preventive agent of POUR for certain ano-rectal and inguinal surgeries.
The efficacy of this prophylactic therapy in transanal endoscopic microsurgery has not been
studied yet and is unclear considering the particularities of this procedure. TEM uses a
rigid proctoscope of four centimeters of diameter and creates a continuous pneumorectum
(insufflation of the rectum during all the procedure). We think that these two elements,
which cause local inflammation, may be part of the reason explaining the high incidence of
post-operative urinary retention after TEM procedures. The objective of our multicenter
clinical trial is to evaluate the effect of perioperative tamsulosin for the reduction of
POUR in men, as well as the impact on the interventions and hospital admissions related to
this complication.