Prophylactic Oxytocin Before Versus After Placental Delivery to Reduce Blood Loss in Vaginal Delivery

• Status: Unknown status
• Trial end date: 2017-09-01
• Target enrollment: 0
• Participant gender: Female

Summary

Randomized controlled study to assess the efficacy and safety of the timing of administration of prophylactic oxytocin via intramuscular route (before compared to after placental delivery) on blood loss in vaginal delivery.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Ain Shams Maternity Hospital
• Treatments: Lactitol; Oxytocin

Criteria

Inclusion Criteria:

1. Multiparous women (had previous one, up to four deliveries)

2. Term pregnancy (37 completed weeks at least).

3. Singleton viable cephalic pregnancy.

4. Vaginal delivery.

Exclusion Criteria:

1. Primigravida.(first pregnancy)

2. Grand multiparous. (had previous 5 or more deliveries)

3. Maternal illness (involving pregnancy induced condition; PIH,GDM or chronic medical condition; hypertension, cardiac , renal problems)

4. Previous cesarean section, uterine surgery.

5. Patients with bleeding tendency.

6. Previous history of Ante-partum hemorrhage.

7. Previous history of postpartum hemorrhage.

8. Abnormal site of the placenta (detected by ultrasound)

9. Macrosomic baby (EFW more than 4000 gm estimated clinically or by ultrasound)

10. polyhydramnios.(detected by ultrasound)

11. Multiple gestation.

12. Chorioamnionitis.

13. Suspected fetal problem(anomaly, distress)

14. Instrumental delivery.

15. Multiple or deep vaginal tears that compromise the estimation of uterine blood loss.

16. Cesarean delivery