Overview
Prophylactic Oral Antibiotics on Sinonasal Outcomes Following Endoscopic Transsphenoidal Surgery for Pituitary Lesions
Status:
Recruiting
Recruiting
Trial end date:
2019-07-01
2019-07-01
Target enrollment:
0
0
Participant gender:
All
All
Summary
To find out whether oral antibiotics given after transsphenoidal endoscopic surgery for pituitary adenoma improves sinus and nasal symptoms, reduces the incidence of infection (sinusitis), and helps mucosal healing in the nasal passages.Phase:
Phase 4Accepts Healthy Volunteers?
NoDetails
Lead Sponsor:
St. Joseph's Hospital and Medical Center, PhoenixCollaborators:
The Cleveland Clinic
Thomas Jefferson UniversityTreatments:
Anti-Bacterial Agents
Antibiotics, Antitubercular
Cefdinir
Cephalosporins
Sulfamethoxazole
Trimethoprim
Trimethoprim, Sulfamethoxazole Drug Combination
Criteria
Inclusion Criteria:- Adult patient undergoing endoscopic surgery for resection of pituitary tumors for
nonfunctioning adenoma, acromegaly, or prolactinoma
- Adults >18 and <85 years of age
- English speaking and able to understand the ASK Nasal-12 and SNOT-22 scales
- Free of any physical, mental, or medical condition which, in the opinion of the
investigator, makes study participation inadvisable
Exclusion Criteria:
- Anaphylaxis/intolerance to the study drugs
- Cirrhosis, hepatitis
- Any solid organ transplant or bone marrow transplant. And any patient felt to be
immunocompromised by the investigators
- Renal failure on dialysis
- Any subject who is unwilling or unable to sign informed consent for the study
- Pregnancy
- Incarcerated patients
- Cushing's disease
- Rathke's Cleft cyst or pituitary cyst
- History of chronic sinusitis
- Anticipated use of nasal splints
- Anticipated use of nasal septal flap
- Active sinusitis
- Nasal polyps
- Previous sinus surgery
- Concurrent antibiotics for another indication (i.e., urinary tract infection)
- Immunodeficiency