Prophylactic Ondansetron in Post-op Cardiac Surgery Patients to Prevent Post-operative Nausea and Vomiting
Status:
Completed
Trial end date:
2018-07-11
Target enrollment:
Participant gender:
Summary
To evaluate the effectiveness of a prophylactic dose of ondansetron in decreasing the
incidence of post-operative nausea and vomiting in cardiac surgery patients after cessation
of post-operative sedation. In patients who have undergone open heart surgery, a single
prophylactic dose of ondansetron 4 mg IV given at the time of discontinuing propofol sedation
will result in a 50% reduction of the rate of post-operative nausea and vomiting in the first
24 post-operative hours compared to placebo.