Prophylactic Mirtazapine or Dexamethasone for Post-spinal Anesthesia Shivering

• Status: Completed
• Trial end date: 2018-08-31
• Target enrollment: 0
• Participant gender: Female

Summary

This study was conducted to evaluate the effect of a prophylactic dose of oral mirtazapine on shivering compared with prophylactic intravenous infusion (IVI) dexamethasone in patients undergoing gynecological surgeries under spinal anesthesia.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ain Shams University
• Treatments: Dexamethasone; Dexamethasone 21-phosphate; Mirtazapine

Criteria

Inclusion Criteria:

• on 300 patients aged 18-60 years

• of the American Society of Anesthesiologists (ASA) physical status I or II

• and underwent gynecological surgeries under spinal anesthesia.

• A written informed consent was obtained from all patients to participate in the study.

Exclusion Criteria:

• Patient's refusal,

• duration of surgery more than 120 min,

• obesity with body mass index (BMI) >35 kg/m2,

• generalized infection or localized infection at level of blockade,

• neurologic disease,

• coagulation disorder,

• patients with hypo- or hyperthyroidism,

• cardiopulmonary disease,

• psychological disorders,

• a need for blood transfusion during surgery,

• an initial body temperature >38.0C or <36.0C,

• a known history of alcohol or substance abuse,

• or receiving vasodilators, or medications likely to alter thermoregulation