Prophylactic Infusion of Calcium Gluconate Reducing the Rate of Hypocalcaemia After Total Thyroidectomy
Status:
Recruiting
Trial end date:
2022-06-01
Target enrollment:
Participant gender:
Summary
Post-total thyroidectomy hypocalcaemia is a common complication with the rate ranging from
13-49% in a meta-analysis. However, the rate in UMMC in 2018 and 2019 were 40% and 23%
respectively. It lead to prolonged hospital stay and patient dissatisfaction in the event of
hypocalcaemia.
Research question: Does prophylactic intravenous calcium infusion reduces the rate of
post-total thyroidectomy hypocalcaemia? This study will conduct in UMMC endocrine surgery
unit with the target population who scheduled for total thyroidectomy in UMMC between
1/6/2020-1/6/2022.
After obtaining consent from participants, they will be randomised into intervention and
placebo group with the ratio of 1:1. Intervention group will receive the intravenous calcium
gluconate infusion and placebo group will receive saline infusion within 4 hour of skin
closure. Both groups will have their serum calcium measure at 6,12,24,36,48-hour mark post
surgery. Both groups will receive same oral calcium supplements.