Overview

Prophylactic Effects of Ondansetron, Ramosetron, and Palonosetron on Patient-Controlled Analgesia Related Nausea and Vomiting After Urologic Laparoscopic Surgery

Status:
Completed
Trial end date:
2011-06-01
Target enrollment:
0
Participant gender:
Female
Summary
The aim of this prospective randomized controlled study was to compare the prophylactic effects of intravenous single dose of ondansetron, ramosetron, and palonosetron on PCA-related nausea and vomiting after urologic laparoscopic surgery.
Phase:
N/A
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Yonsei University
Treatments:
Ondansetron
Palonosetron
Ramosetron
Criteria
Inclusion Criteria:

- ASA I or II

- Patients aged (20-65 yr) Undergoing Laparoscopic Nephrectomy

- Patients who want a patient-controlled IV analgesia (IV-PCA)

Exclusion Criteria:

- History of allergy or hypersensitivity to 5-HT3 antagonist

- History of severe postoperative nausea/vomiting

- Prolonged QT interval on preoperative EKG

- Hypokalemia, Hypomagnesemia

- Intestinal obstruction

- Pregnant female or breast feeding mother