Prophylactic Antibiotics for Surgical Site Infections and Beta-Lactam Allergy
Status:
Not yet recruiting
Trial end date:
2023-08-01
Target enrollment:
Participant gender:
Summary
Postoperative surgical site infection (SSI) is associated with unnecessary use of heath care
resources including prolonged hospitalization and increased hospital readmission.
Perioperative antibiotic prophylaxis is one of the most important strategies for prevention
of SSI. If there is a beta-lactam allergy, second tier antibiotics (vancomycin and
clindamycin) are recommended alternatives to first- and second-generation cephalosporins
because of fears of possible allergy.
This prospective, randomized, and single-blinded clinical trial is designed to examine
causality between second tier antibiotics use and surgical site infections in the subjects
with a documented unverified penicillin allergy. Unverified beta-lactam allergy could be
associated with antimicrobial treatment failure with second tires antibiotics during
postoperative period.