Prophylactic Analgesic and Antiemetic Regimen for Medical Abortion < 70 Days

• Status: Not yet recruiting
• Trial end date: 2025-03-30
• Target enrollment: 0
• Participant gender: Female

Summary

Randomized trial which will aim to evaluate whether prophylactic use of ondansetron and ibuprofen will decrease side effects associated with medical abortion and increase patient satisfaction.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Hackensack Meridian Health
• Treatments: Ibuprofen; Misoprostol; Ondansetron

Criteria

Inclusion Criteria:

• Healthy

• English speaking

• female volunteers undergoing medical abortion whether for voluntary interruption of pregnancy or missed abortion

• Gestational age
• Access to a time keeping device

• Willingness to complete a telephone or in-clinic follow up

Exclusion Criteria:

• chronic medical problems including but not limited to cardiac conditions, malignancy or organ damage

• Failed medical abortion resulting in surgical management

• Known intrauterine infection

• Known allergy to ondansetron or ibuprofen

• Subjects chronically receiving analgesic drugs

• Subjects unable to give consent

• Subjects taking medications that interact with ondansetron or ibuprofen