Proof of Concept of an Anaplerotic Study Using Brain Phosphorus Magnetic Resonance Spectroscopy in Huntington Disease

• Status: Completed
• Trial end date: 2013-07-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this project is to study the efficacy of an anaplerotic treatment on brain energy profile evolution at an early stage of the Huntington disease.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Institut National de la Santé Et de la Recherche Médicale, France

Criteria

Inclusion Criteria:

• 5 < UHDRS < 50

• Age > 18 years

• Ability to undergo MR scanning

• Covered by french social security

Exclusion Criteria:

• Evidence of psychiatric disorder

• Attendant neurological disorder

• Contraindications to MRI (claustrophobia, metallic or material implants)

• Severe head injury

• Unable to understand the protocol

• Pregnancy

• Failure to give informed consent

• Subjects with exclusion criteria required by french law (e.g. subjects who require a legally authorized representative to obtain consent)

• Unwillingness to be informed in case of abnormal MRI