Pronase in Improving Endoscopic Mucosal Clarity During Colonoscopy for Patients with Colitis
Status:
NOT_YET_RECRUITING
Trial end date:
2025-11-30
Target enrollment:
Participant gender:
Summary
Pronase is a proteolytic enzyme known for its ability to clear mucus by breaking down its main component, mucin, through enzymatic hydrolysis. This property makes it useful in gastroscopy, where it is employed to improve the visibility of the mucosal surface during endoscopic examinations. Given the same mechanism, pronase may also be beneficial in enhancing mucosal clarity during colonoscopy. This multicenter, prospective, double-blind randomized controlled trial is designed to assess the effectiveness and safety of pronase in improving mucosal visibility in patients with colitis during endoscopy.
Phase:
NA
Details
Lead Sponsor:
Changhai Hospital
Collaborators:
Affiliated Hospital of Jiangnan University Dongfang Hospital Affiliated to Tongji University Huadong Hospital Huashan Hospital Jinshan Hospital Fudan University Shanghai 8th People's Hospital Shanghai Baoshan District Wusong Central Hospital Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University Shanghai Pudong Hospital Shanghai Pudong New Area Gongli Hospital Shanghai Songjiang District Central Hospital The Affiliated People's Hospital of Ningbo University The People's Hospital of Leshan