Pronase Improves Efficacy of Chromoendoscopy Screening on Esophageal Cancer
Status:
Completed
Trial end date:
2014-12-01
Target enrollment:
Participant gender:
Summary
Lugol's solution staining was regarded as a gold standard to detect early superficial lesion
during esophageal cancer screening using endoscopy. However, the sensitivity and specificity
were influenced by mucus and food debris of esophagus. Pronase, a kind of protease, was
previously shown to improve the visibility of gastrointestinal tract. It's unknown if the
pre-treatment with pronase would also improve the quality of iodine staining in esophagus.A
randomized double-blind clinical trial was designed to investigate whether or not pronase
might improve detection rate of early esophageal lesion, especially high grade dysplasia and
early cancer by improving the esophageal visibility.