Prolonged or Standard Infusion of Cefepime Hydrochloride in Treating Patients With Febrile Neutropenia

• Status: Completed
• Trial end date: 2012-10-01
• Target enrollment: 0
• Participant gender: All

Summary

This randomized pilot clinical trial studies how well giving prolonged infusion compared to standard infusion of cefepime hydrochloride works in treating patients with febrile neutropenia. Giving cefepime hydrochloride over a longer period of time may be more effective than giving cefepime hydrochloride over the standard time.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Wake Forest University Health Sciences
• Collaborator: National Cancer Institute (NCI)
• Treatments: Cefepime; Cephalosporins

Criteria

Inclusion Criteria:

• Absolute neutrophil count < 500 cells/mm^3 or < 1000 cells/mm^3 with a predicted decrease to < 500 cells/mm^3

• Temperature > 38.0 degrees Celsius

• Received chemotherapy or stem-cell transplant as treatment for malignancy or myelodysplastic syndrome (MDS)

• Cefepime prescribed at a dose of 2 grams IV every 8 hours

Exclusion Criteria:

• Allergy to a cephalosporin antibiotic

• Estimated creatinine clearance < 50 milliliters/minute

• Concurrent anti-gram negative antimicrobials

• Diagnostic criteria suggestive of sepsis

• Circumstances which may make 3 hour infusion impractical

• Solid tumor malignancy