Prolonged Popliteal Fossa Nerve Blockade (Prolonged Pop)

• Status: Completed
• Trial end date: 2014-02-01
• Target enrollment: 0
• Participant gender: All

Summary

This study looks at addition of medications to the local anesthetic for the nerve blockade.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Hospital for Special Surgery, New York
• Treatments: BB 1101; Buprenorphine; Dexamethasone; Dexamethasone 21-phosphate; Dexamethasone acetate

Criteria

Inclusion Criteria:

• Patients of Dr. Levine or Dr. Roberts at Hospital for Special Surgery

• Patients aged 18-75

• Patients scheduled for discharge from HSS after foot or ankle surgery

• A single-injection popliteal fossa nerve block is judged appropriate

• Surgery confined to foot and ankle (no iliac crest bone graft planned - iliac aspirate is not an exclusion criterion)

Exclusion Criteria:

• < 18 and > 75

• Surgery that will cause pain at sites outside the distal lower extremity (e.g. iliac crest bone graft)

• Bilateral surgery

• Chronic pain (defined as regular use of opioid analgesics for > 3 months)

• Chronic use of steroids (defined as regular use of steroids for > 3 months)

• Contraindication to performance of the popliteal fossa nerve block with 30 cc 0.25% bupivacaine (e.g. alleged bupivacaine sensitivity, low body weight, etc.)

• Contraindications to dexamethasone or buprenorphine (e.g. allergy, insulin dependent diabetes mellitus, etc.)

• Patients who have been diagnosed with altered pain perception or have lack of sensation

• Inability of the patient to describe postoperative pain (e.g. psychiatric disorder, dementia)

• Non-English speaking patients (the questionnaire is in English, and translations would have to be separately validated)