Prolonged Anticoagulation After a First Episod of Idiopathic Proximal Deep Vein Thrombosis (PADIS TVP)
Status:
Completed
Trial end date:
2017-01-01
Target enrollment:
Participant gender:
Summary
In a French multicenter double blind randomized controlled trial, the main objective is to
demonstrate that, after 6 months of oral anticoagulation for a first episode of idiopathic
proximal deep vein thrombosis, 18 months of warfarin therapy is associated with a lower
cumulative risk of recurrent VTE and major bleeding in comparison with that on 18 months of
placebo. The secondary objectives are: (1) to determine the risk of recurrent VTE after 6
months of warfarin therapy and the presence or the absence of residual lung scan perfusion
defect and the persistence or not of elevated D-dimer test; and (2), to determine the impact
of extended duration of anticoagulation on the risk of VTE after stopping anticoagulant
therapy on a follow-up of 2 years.