Project OOPEN: Opioid Overdose Prevention, Education and Intervention
Status:
Completed
Trial end date:
2018-10-01
Target enrollment:
Participant gender:
Summary
This prospective, randomized emergency department trial will study the effectiveness of an
intervention that combines opioid overdose prevention, education and intervention that
includes take home naloxone with brief behavioral change counseling. The study will recruit
both heroin users (n=500) and pharmaceutical opioid users at elevated risk for overdose
(n=500). Outcomes of interest include subsequent opioid overdoses and overdose risk
behaviors.
Primary Aims
The primary aims are to test whether those who receive the intervention compared to standard
care have: 1) Lower rates of opioid non-fatal and fatal overdose; 2) Reduce drug use,
inappropriate medication use, and other overdose risk behaviors.
Secondary Aims
The secondary aims are to test whether those who receive the intervention compared to
standard care have: 3) More appropriate health care utilization (e.g. fewer emergency
department visits and admissions to inpatient care); 4) Lower total health care costs; 5)
Determine the prevalence of HIV risk behaviors among heroin and pharmaceutical opioid users
at risk for overdose and whether the intervention impacts these behaviors.