Project 4B: Lower Extremity Strength Training in ICU Patients
Status:
Completed
Trial end date:
2016-07-15
Target enrollment:
Participant gender:
Summary
The purpose of this research study is to see if electrical stimulation of the leg muscles
will improve strength in patients receiving mechanical ventilation in the intensive care unit
(ICU). ICU care frequently results in chronically critically ill (CCI) patients. Some CCI
patients develop persistent inflammation/immunosuppression and catabolism syndrome (PICS),
and they have morbid long-term outcomes. CCI patients with PICS often develop severe limb
muscle atrophy, weakness and accelerated protein catabolism. Limb muscle dysfunction in PICS
is due to many factors including sepsis/inflammation, proteolysis, apoptosis, and inactivity.
Despite the seriousness of limb muscle weakness in CCI patients receiving mechanical
ventilation, little is known about exercise strategies to treat this problem. There is
limited knowledge about how strength training impacts inflammation and catabolism in CCI
patients. In addition, an assessment of the effect of exercise on markers of inflammation and
protein catabolism on muscle samples obtained with biopsy techniques and venous blood samples
will be performed. This project will further understanding of how treating CCI-related muscle
weakness with strength training cannot only improve muscle function, but also potentially
blunt the inflammation and catabolism of PICS.
Phase:
N/A
Details
Lead Sponsor:
University of Florida
Collaborators:
National Institute of General Medical Sciences (NIGMS) National Institutes of Health (NIH)