Project 1 Aim 2, Adaptations of the Brain in Chronic Pain With Opioid Exposure
Status:
Recruiting
Trial end date:
2023-04-01
Target enrollment:
Participant gender:
Summary
This study is designed to track brain functional changes in individuals with i) chronic back
pain + opioid use (CBP+O) and individuals with ii) chronic back pain + opioid misuse disorder
(CBP+mOUD) following a brief drug delay and re-exposure manipulation. Re-exposure could be
placebo, the participant's own opioid dose, or a dopaminergic treatment (DA+NSAID). The
participants will be also evaluated for changes in cognition, emotion, and motor abilities
with opioid delay and re-exposure to placebo, opioid, or DA+NSAID.
Phase:
Phase 2
Details
Lead Sponsor:
Northwestern University
Collaborators:
National Institutes of Health (NIH) Shirley Ryan AbilityLab
Treatments:
Acetaminophen Acetaminophen, hydrocodone drug combination Carbidopa Carbidopa, levodopa drug combination Codeine Hydrocodone Levodopa Morphine Naproxen Oxycodone Oxymorphone Tramadol