Prognostic Influence of Light Rheography Measurement of Patients With Secondary Raynaud Syndrome With Ulcers on Hands

• Status: Unknown status
• Trial end date: 2015-09-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to evaluate the prognostic influence of light rheography measurement at the fingertips from subjects with secundary Raynaud syndrome.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Christoph Hehrlein
• Collaborator: Actelion
• Treatments: Alprostadil; Bosentan

Criteria

Inclusion Criteria:

• Subjects with Limited or diffuse systemic sclerosis/scleroderma with at least one ulcera at fingertip

• Age > 18 Years

• Weight > 40 Kg

Exclusion Criteria:

• Sympathectomy

• Ulcers due to other condition (PVD, DM, Thromboangiitis obliterans etc.)

• Antibiotic concomitant medication

• Therapy with Prostanoids within the last 4 weeks

• Previous Bosentan therapy

• Severe liver and renal insufficiency(creatinin >2.0 mg/dl;AST/ALT > 3X UNL)

• severe cardiac- pulmonal diseases

• Untreated or therapy refractory Hypertension

• Noncompliance

• Pregnancy or nursing (Pregnancy test required)