Progesterone in the Treatment of Acute Hemorrhagic Stroke
Status:
Unknown status
Trial end date:
2020-12-31
Target enrollment:
Participant gender:
Summary
A large number of preclinical studies have confirmed that progesterone and its metabolites
have strong neuroprotective effects. As a neuroprotective agent, progesterone has been
effective in several animal models of nerve injury, suggesting that the drug has a wide range
of neuroprotective effects. Pharmacodynamic studies have shown that some characteristic
mechanisms of the action of the neurosteroid on brain injury and cerebral congestion include:
prevention of inflammatory reaction and cell death (by inhibiting the activation of
inflammatory cytokines and microglia); control of angiogenic brain edema (by reestablishing
blood-brain barrier and regulating aquaporin-4 water transporter) and cytotoxic edema (by
regulating Progesterone can also improve the neural dysfunction after cerebral hemorrhage,
promote the regeneration and repair of damaged axons (activate PI3K / Akt pathway to inhibit
the expression of RhoA), prevent the loss of Ca2 + caused by excitotoxicity and improve the
survival rate of neurons. It was found that progesterone injection could reduce brain edema
and promote the recovery of nerve function after brain injury.
Phase:
Phase 4
Details
Lead Sponsor:
Second Affiliated Hospital, School of Medicine, Zhejiang University
Collaborators:
Huizhou Municipal Central Hospital Huzhou Central Hospital Jinhua Central Hospital Korea University Anam Hospital Lishui Country People's Hospital Seoul National University Hospital The Affiliated Hospital of Hangzhou Normal University