Progesterone for the Management of Preterm, Premature Rupture of the Membranes: A Randomized Controlled Trial.
Status:
Completed
Trial end date:
2015-12-01
Target enrollment:
Participant gender:
Summary
Preterm birth is the leading cause of neonatal death and a significant cause of life long
disability and health problems. It has been shown that the drug 17-hydroxyprogesterone
caproate can help reduce the risk of preterm delivery in women with certain risk factors for
preterm birth. We hope to learn whether this same medication can be used to prolong pregnancy
in a group of patients in whom this medication has not been previously studied. Specifically,
we hope to learn whether progesterone supplementation will delay delivery in women with
pre-term, premature rupture of membranes (PPROM).