Progesterone and Muscle Protein Synthesis in Premenopausal Women (MP4-MPS)
Status:
NOT_YET_RECRUITING
Trial end date:
2025-12-15
Target enrollment:
Participant gender:
Summary
The goal of this clinical trial is to learn if micronized progesterone (PROMETRIUM) influences the muscle-building response to resistance exercise in healthy premenopausal women aged 18-30 years.
The main questions it aims to answer are:
1. Does progesterone change the rate of muscle protein synthesis after exercise?
2. Does progesterone alter the difference in synthesis between an exercised leg and a rested leg?
Researchers will compare micronized progesterone to a placebo to see if progesterone changes the way skeletal muscle adapts to resistance exercise.
Participants will:
* Take two oral doses of progesterone (400 mg total, 34 and 10 hours before testing) or placebo
* Complete a unilateral leg extension exercise session in the lab
* Receive an infusion of a stable isotope tracer and provide blood samples
* Undergo muscle biopsies from the exercised and rested legs