Progesterone Suppression of Nocturnal LH Increases in Pubertal Girls
Status:
Completed
Trial end date:
2009-06-08
Target enrollment:
Participant gender:
Summary
The purpose of this study is to learn more about how gonadotropin-releasing hormone (GnRH)
and luteinizing hormone (LH) pulses are controlled during puberty. In this study, the
investigators aim to discover whether or not giving 2 small doses of progesterone to early
pubertal girls will prevent the nighttime increase of GnRH and LH pulses. From the
information gathered in this study, the investigators may be able to learn more about how
menstrual cycles are normally established in girls during puberty. Ultimately, if these
normal processes can be understood, the investigators may be able to better understand
abnormalities of puberty.
Phase:
Phase 1
Details
Lead Sponsor:
University of Virginia
Collaborator:
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)