This clinical trial was conducted on 90 IBS patients, who fulfill ROME IV criteria and the
IBS diagnostic questionnaire (Arabic version licensed by Rome Foundation) in Egyptair
hospital outpatient clinic, Cairo, Egypt between May and December 2019. Data of the patient,
with suspected IBS during the study period, were reviewed and the patients who fulfilled the
inclusion criteria were enrolled into this study. A written consent was obtained from all
included patients. The patients who agreed to participate were then randomly assigned into
two equal groups and were followed up after 4 weeks from the first visit.