Probiotic Lozenges for Treatment of Recurrent Aphthous Stomatitis
Status:
Completed
Trial end date:
2019-04-21
Target enrollment:
Participant gender:
Summary
The application of host-modulating bacteria for therapeutic purposes is one of the strongest
emerging fields. Probiotics are live microorganisms, which, when administered in an adequate
amount, confer a health benefit on the host The study aimed to explore the effectiveness of
probiotics in the treatment of the common ulcerative condition; minor recurrent aphthous
stomatitis (RAS). We included sixty adult (group A) and 60 children patients (group B) with
diagnosis of minor RAS . Both groups were divided into two subgroups, AI and BI (test
subgroups ) and AII and BII (control subgroups). For test subgroups, probiotic lozenges were
consecutively administered twice daily, for five days. The size and pain level of ulcers were
recorded on treatment days 0, 3 and 5. The outbreak frequency of RAS within 6 months was
investigated for all subgroups.