Proactive Management of Endoperitoneal Spread in Colonic Cancer
Status:
Not yet recruiting
Trial end date:
2025-09-01
Target enrollment:
Participant gender:
Summary
This study aims to determine the oncological effectiveness, compared to standard surgical
treatment, of proactive management including target organs for peritoneal spread resection
(omentectomy, bilateral adnexectomy, appendectomy, hepatic round ligament resection) and
preventive HIPEC (intraperitoneal oxaliplatin with concomitant i.v.
5-fluorouracil/leucovorin) following a curative resection of high-risk ( >/= 5 mm tumor
invasion beyond the muscularis propria) T3 and T4 colon cancer in preventing the development
of peritoneal metastases. Adjuvant systemic chemotherapy will be reserved in both groups for
patients with poor prognostic factors according to Folinic acid/Fluorouracil/Oxaliplatin
(FOLFOX) or to Capecitabine/Oxaliplatin (CAPOX) regimens.
Hypothesis:
The hypothesis is that compared to the standard treatment proactive management following
curative resection of high-risk T3 and T4 colon cancer will reduce the development of
endoperitoneal metastases