Preventive Effects of Penehyclidine Hydrochloride Inhalation on Postoperative Pulmonary Complications
Status:
Completed
Trial end date:
2018-12-10
Target enrollment:
Participant gender:
Summary
Postoperative pulmonary complications (PPCs) are major causes of postoperative morbidity,
mortality, and prolonged hospital stay.The incidence of PPCs may be as high as 41% to 75% in
high-risk patients. Bronchodilator is frequently used in high-risk patients to prevent PPCs.
Penehyclidine is a new anticholinergic agent which selectively block M1 and M3, but not M2
receptors. A pilot study of the investigators showed that prophylactic penehyclidine
inhalation reduced the incidence of bronchospasm and the use of aminophylline in elderly
patients after long-duration surgery. The purpose of this study is to investigate whether
prophylactically penehyclidine inhalation could decrease the incidence of PPCs in high-risk
patients after major intrathoracic and upper intraabdominal surgery.