Preventive Effect of Pitavastatin on Contrast-Induced Nephropathy in Patients With Renal Dysfunction
Status:
Unknown status
Trial end date:
2014-02-01
Target enrollment:
Participant gender:
Summary
Contrast-induced nephropathy (CIN) is a well-recognized complication of radiographic contrast
administration and is associated with increased short- and long-term mortality. Previous
strategies including forced diuresis with diuretics or mannitol, intravenous administration
of fenoldopam or dobutamine, and postprocedure hemodialysis to prevent CIN have been largely
unsuccessful. In addition, the use of N-acetylcysteine to prevent CIN has yielded conflicting
outcomes.
A review of a large insurance database and retrospective study have shown that statins
therapy is associated with a lower incidence of CIN after percutaneous coronary intervention.
The preventive effect of statins on CIN may be attributed to direct pleiotropic effects on
the vascular wall such as improvement of endothelial dysfunction, anti-inflammatory or
anti-oxidative effect. However, recent randomized trial could not demonstrate the preventive
effect of statin on CIN in patients with chronic kidney disease.
Thus, we will investigate the preventive effect of pitavastatin on CIN in patient with renal
dysfunction undergoing coronary angiography or intervention.
Phase:
Phase 4
Details
Lead Sponsor:
Gachon University Gil Medical Center
Collaborators:
Bundang CHA Hospital Dankook University Eulji General Hospital Gangnam Severance Hospital Inje University Myongji Hospital National Health Insurance Service Ilsan Hospital Severance Hospital