Preventive Arterial Wall Phenotype and Low-dose Fluvastatin/Valsartan Combination

• Status: Completed
• Trial end date: 2017-06-01
• Target enrollment: 0
• Participant gender: Male

Summary

The study was designed to test whether short-term treatment with a very low-dose combination of fluvastatin and valsartan could induce improvement of endothelial function, arterial stiffness, vascular inflammation, oxidative stress and expression of protective genes in subjects with moderate cardiovascular risk.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University Medical Centre Ljubljana
• Treatments: Valsartan

Criteria

Inclusion Criteria:

• moderate cardiovascular risk according to Systematic Coronary Risk Estimation (SCORE) risk charts of the European Society of Cardiology

• males

• aged between 40 and 55 years

Exclusion Criteria:

• diabetes mellitus

• manifest peripheral artery disease or carotid artery disease

• acute infection

• chronic diseases

• present therapy with fluvastatin and/or valsartan