Prevention of Very Preterm Delivery by Testing for and Treatment of Bacterial Vaginosis
Status:
Completed
Trial end date:
2011-06-01
Target enrollment:
Participant gender:
Summary
Background. Anomalies of the vaginal flora (bacterial vaginosis, BV) are associated with an
increased risk of late abortions and preterm birth. Studies of antibiotic treatment of BV to
reduce the risk of prematurity have not found a statistically significant diminution of risk
(<= 32 wks: OR=0.49 [0.05-5.1], < 37 wks: OR=0.83 [0.59-1.17]).A partial explanation of these
findings is that some of these treatment were administered vaginally, most often during the
second or third trimester
Aim: To reduce the frequency of late abortions and very preterm birth by prescribing
clindamycin vs placebo to patients diagnosed with BV before 13 weeks.