Prevention of Unexplained Recurrent Abortion by Enoxaparine
Status:
Terminated
Trial end date:
2014-09-01
Target enrollment:
Participant gender:
Summary
Standard investigations fail to reveal any apparent cause in 50% of the cases of recurrent
spontaneous abortion. Prothrombotic mechanisms were initially evoked. Factor V Leiden,
Prothrombin G20210A mutation and protein S deficiency are implicated in the meta-analysis of
Rey (Lancet).However, they do not account for a large number of miscarriages.Gris JC and
coworkers (Blood 2004)carried out an open trial, low-molecular-weight heparin versus low-dose
aspirin, in women with one fetal loss and with a constitutional thrombophilic disorder. They
conclude for a benefit action of Low-molecular-weight heparin. There is actually no trials
concerning women with unexplained recurrent abortions and without known thrombophilia.
Nevertheless,aspirin or enoxaparin are often prescribed. It is time to assess these
practices. We therefore initiate a multisite, double blind randomized study, enoxaparine
versus placebo, in women without known thrombophilia, which experienced unexplained recurrent
abortions.