Overview

Prevention of Transfusion Related Acute Gut Injury (TRAGI) in Extremely Low Gestational Age Neonates (ELGANs) Using iNO

Status:
Unknown status

Trial end date:
2021-06-30

Target enrollment:

Participant gender:

Summary

The investigators seek to determine whether providing inhaled nitric oxide (iNO; a vasodilator) will improve the delivery of oxygen to the brain, kidney and intestines of preterm neonates during and after the subject receives a packed red blood cell transfusion (PRBC) for anemia vs. baseline period. The investigators will observe the effect of inhaled nitric oxide vs. placebo at these body sites to determine whether iNO will alter the fractional tissue oxygen extraction. Treatment and control groups will be compared to each other at equivalent epochs as will individual patients before, during and after the PRBC transfusion.

Phase:

Phase 1/Phase 2

Details

Lead Sponsor:

New York Medical College

Collaborators:

Baystate Medical Center
East Carolina University
New York University
Stony Brook University

Treatments:

Nitric Oxide