Prevention of Stimulant-Induced Euphoria With an Opioid Receptor Antagonist
Status:
Completed
Trial end date:
2015-06-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to a) assess the efficacy of naltrexone in preventing
stimulant-induced euphoria in adults with ADHD, b) assess whether naltrexone will interfere
with the clinical efficacy of stimulants in treating adults with ADHD, c) assess whether
naltrexone will interfere with the effects of stimulants on neurotransmitter activity. We
predict that naltrexone will successfully prevent stimulant-induced euphoria without
interfering with the ability of stimulants to effectively treat ADHD in adults. This study
will be an 8 -week trial with young adults (18-24) with ADHD.
Phase:
Phase 4
Details
Lead Sponsor:
Massachusetts General Hospital
Collaborator:
United States Department of Defense
Treatments:
Central Nervous System Stimulants Naltrexone Narcotic Antagonists