Prevention of Remifentanil-induced Postoperative Hyperalgesia With Intravenous Ibuprofen

• Status: Completed
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

Postoperative hyperalgesia has been reported after intraoperative administration of small or high-dose remifentanil. Cyclooxygenase inhibitor exhibit preventive effects on the development of opioid-induced hyperalgesia. The aim of this study is to evaluate the preventive effect of intravenous ibuprofen (Caldolor®) on remifentanil-induced hyperalgesia

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Seoul National University Hospital
• Treatments: Ibuprofen; Remifentanil

Criteria

Inclusion Criteria:

• Adult patients scheduled for elective pancreaticoduodenectomy

Exclusion Criteria:

• Patients with chronic pain

• Patients with psychiatric disease

• Patients with nonsteroidal antiinflammatory drugs allergy

• Patients with renail dysfunction

• History of drug addiction

• Pregnant patient

• Inability to use a PCA device