Prevention of Recurrent UTI Using Vaginal Testosterone Versus Placebo Placebo
Status:
Recruiting
Trial end date:
2022-09-01
Target enrollment:
Participant gender:
Summary
Women over the age of 60 years have an estimated 10 to 15 % risk of recurrent urinary tract
infections (UTI). This is believed to be due to hormonally induced changes in the vaginal
flora associated with menopause. After menopause, there is a chemical changes in the vagina
that may predispose to bacterial infections.
The role of vaginal estrogen creams to restore vaginal atrophy and prevent urinary tract
infections has been well characterized. Vaginal testosterone (VT) application use in
postmenopausal breast cancer patients on aromatase inhibitors have been shown to improve
vaginal pH, vaginal atrophy symptom scores, dyspareunia, and vaginal dryness. Although
testosterone has been used to improve sexual function in postmenopausal women, the effects of
VT on vaginal flora and recurrent UTIs are unknown.
The purpose of this study is to determine whether topically applied vaginal testosterone
cream is more effective than placebo in reducing the incidence of urinary tract infections in
postmenopausal women with recurrent urinary tract infections and to ascertain the effects of
topical estrogen on the vaginal pH and flora.