Prevention of Pregnancy-associated Malaria in HIV-infected Women: Cotrimoxazole Prophylaxis Versus Mefloquine

• Status: Completed
• Trial end date: 2012-12-01
• Target enrollment: 0
• Participant gender: Female

Summary

The purpose of this study is to evaluate the efficacy of cotrimoxazole prophylaxis in prevention of malaria during pregnancy in HIV-infected women, compared to intermittent preventive treatment with mefloquine.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Institut de Recherche pour le Developpement
• Collaborators: Ministry of Health, Benin; National University Hospital, Cotonou; Saint Antoine University Hospital; Sidaction; Université d'Abomey-Calavi
• Treatments: Mefloquine; Trimethoprim, Sulfamethoxazole Drug Combination

Criteria

Inclusion Criteria:

• Confirmed HIV seropositivity

• Permanent residency in the study catchment's area

• Confirmed pregnancy, gestational age< 28 weeks

• More than 18 years of age

• Karnofsky index ≥80

• Willingness to deliver at the hospital

• Written informed consent

Exclusion Criteria:

• History of allergy to study drugs : sulpha drugs, mefloquine, quinine

• History or presence of major illnesses : severe renal disease , severe hepatic disease, severe neuropsychiatric disease

• Mefloquine or halofantrine received within the 4 weeks prior to enrolment