Prevention of Postoperative Nausea and Vomiting in Patients Undergoing Vitrectomy Under Local Anesthesia
Status:
Unknown status
Trial end date:
2015-09-01
Target enrollment:
Participant gender:
Summary
Vitreoretinal surgery is associated with a considerable incidence of postoperative nausea and
vomiting (PONV), which is reported to be as high as 60%. Reasons for this high incidence may
be the long duration of surgery and anesthesia and the high degree of manipulation of the
eye. Postoperative vomiting after vitrectomy is an important risk factor for the onset of
several complications, such as suprachoroidal hemorrhage, with disastrous visual
consequences.
To date there is no evidence as to the possible protective effect of anti-emetic therapy with
regard to interventions of vitrectomy performed under local anesthesia.
In this prospective, randomized, multicenter, double blind study, we evaluated the efficacy
of Ondansetron alone, Dexamethasone alone and in combination in controlling nausea and
vomiting in patients undergoing vitrectomy under local anesthesia.