Overview

Prevention of Post-traumatic Seizures With Levetiracetam

Status:
Terminated
Trial end date:
2010-05-01
Target enrollment:
0
Participant gender:
All
Summary
Post-traumatic seizures can appear frequently after a severe traumatic brain injury. Two types of seizures are usually identified: early seizures during the week following the trauma and late epilepsy afterward. Several antiepileptic drugs are usually used to prevent early seizures but no treatment has demonstrated any preventive effect against late epilepsy. Levetiracetam is an antiepileptic drug usually used for the treatment of epileptic patients and has pharmacologic properties that could also be interesting for the prevention of post-traumatic epilepsy.
Phase:
Phase 3
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Rennes University Hospital
Collaborator:
UCB Pharma
Treatments:
Etiracetam
Levetiracetam
Piracetam
Criteria
Inclusion Criteria:

1. Age >= 18 years old

2. Patient with severe brain injury defined as follow:

- Initial Glasgow Coma score (assessed on the scene of the accident) <= 8 related
to the brain injury

- Stage 2 to 4 on the TDM US TCDB classification

3. Initial brain CT scan performed within 48 hours after hospital admission

4. Either a male or a nonpregnant, non-lactating female who is using adequate
contraceptive method (a urine laboratory pregnancy test must be negative at baseline)

5. Written informed consent from the patient's next-of-kin. If no relative is present as
the time of inclusion, the patients will be included according to the emergency
procedure

Exclusion Criteria:

1. Isolated extradural hematoma

2. Medical decision to limit patient's care (terminal stage of a cancer, hematological
malignancies, HIV, etc.)

3. Current participation in an other protocol or within one month before study entry

4. Previous treatment with Levetiracetam

5. Patient's follow-up judged to be difficult by the investigator

6. Known allergy to either Levetiracetam or products derived from pyrrolidone or one of
its excipients

7. Epileptic patient treated or not (except patients treated with benzodiazepines who can
be included in this protocol)