Prevention of Mild-to-moderate Hypoglycemia in Type 1 Diabetes
Status:
Recruiting
Trial end date:
2023-12-31
Target enrollment:
Participant gender:
Summary
According to guidelines, when a mild-to-moderate hypoglycemia occurs (capillary blood glucose
< 4.0 mmol/L), 15-20g of rapidly absorbed carbohydrates should be ingested. Patients should
re-test and re-ingest 15-20g carbohydrates every 15 minutes until they recover from
hypoglycemia. These recommendations were principally based on two studies conducted in the
80s before the introduction of intensive insulin therapy. In practice, only 32-50% of
patients follow the current guidelines. In addition, recent studies suggest that under
current intensive insulin therapies, an initial correction with 15g of oral glucose may be
insufficient to rapidly correct mild-to-moderate hypoglycemia. With the development and
increasing usage of newer glucose monitoring technologies, the community is witnessing a
shift in hypoglycemia management, from a reactive to a proactive approach (e.g., prevent
imminent episodes rather than treating established episodes).