Prevention of Intraoperative Bleeding and Postoperative Swelling in Orthognathic Surgery Through the Use of Tranexamic Acid
Status:
Completed
Trial end date:
2016-09-26
Target enrollment:
Participant gender:
Summary
Purpose of the study:
- To evaluate the effect of tranexamic acid (TXA) of intraoperative blood loss in patients
subjected to bi-maxillary orthognathic surgery
- To evaluate the potential effect of TXA on fibrin structure
- To evaluate the potential effect of TXA of binding of plasminogen to fibrin
- To evaluate the potential effect of TXA on postoperative edema formation.
Hypothesis:
H0: Intraoperative bleeding cannot be significantly reduced by preoperative administration of
tranexamic acid
H0,1: Postoperative edema cannot be significantly reduced by preoperative administration of
tranexamic acid
Phase:
Phase 4
Details
Lead Sponsor:
Hospital of South West Denmark
Collaborators:
University of Copenhagen Vestjydsk Ortopædisk Fond