Overview

Prevention of Infections in Cardiac Surgery (PICS) Prevena Study

Status:
Recruiting

Trial end date:
2022-02-01

Target enrollment:
0

Participant gender:
All

Summary

This vanguard study will be conducted at two study sites in Canada. It is a cluster randomized trial to test a combination of two antibiotics for antibiotic prophylaxis as compared to routine prophylaxis with one single antibiotic, and to test a negative-pressure wound management system (Prevena) versus standard wound dressing to reduce chest wound infections.

Phase:

Phase 4

Accepts Healthy Volunteers?

Details

Lead Sponsor:

Population Health Research Institute

Treatments:

Anti-Bacterial Agents
Antibiotics, Antitubercular
Cefazolin
Vancomycin

Criteria

Inclusion Criteria:

- ≥18 years of age undergoing open-heart surgery (sternotomy, including minimally-invasive
sternotomies)

Exclusion Criteria:

- On systemic antibiotics or with an active bacterial infection at the time of surgery

- Patients previously enrolled in this trial

- Patients known to be colonized with Methicillin-resistant S. aureus (MRSA)(unethical
not to administer glycopeptides), beta-lactam or vancomycin allergy precluding the use
of cefazolin or vancomycin, respectively, or to silver precluding the use of Prevena

- Participation in other studies that may interfere with this trial