Prevention of Infection in Closed Fractures: Cefazolin Versus Vancomycin

• Status: Terminated
• Trial end date: 2017-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to compare the incidence rate of infection in surgical patients with closed fractures treated prophylactically with Cefazolin versus Vancomycin in the peri-operative period.

The hypothesis of this study is that patients undergoing surgical treatment for closed fractures who are treated prophylactically with Vancomycin will have a lower incidence rate of infection than patients who are treated prophylactically with Cefazolin.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Tennessee
• Treatments: Cefazolin; Vancomycin

Criteria

Inclusion Criteria:

• Between 18 years old and 85 years old

• Closed fracture

• Fracture treatment plan is for one operation on one day (one surgical setting)

• Likely to follow-up with surgeon until fracture is healed

• Ability to understand and agree to Informed Consent

Exclusion Criteria:

• Under 18 years old or over 85 years old

• Open fracture(s)

• Fracture requires multiple operations

• Other injuries requiring operations

• Documented allergy to Cefazolin or Vancomycin

• Previous history of Methicillin-resistant Staphylococcus aureus infection

• Previous surgery on the injured extremity within 1 year

• Use of antibiotics within 2 weeks before or after injury

• Use of antibiotics within 2 weeks before surgery

• Unlikely to follow-up until fracture is healed

• Unable to understand and agree to Informed Consent