A double-blind placebo controlled study
- To compare the effect of tadalafil and dexamethasone versus placebo on Ppa and pulmonary
edema formation in subjects susceptible to HAPE.
- To investigate the effect of dexamethasone on alveolar fluid clearance, as assessed by
measurement of the nasal potential difference, and prevention of HAPE.
- To investigate the effect of the tadalafil and dexamethasone versus placebo on the
dynamic CBF autoregulation properties and on the development of AMS in HAPE susceptible
subjects.