Prevention of Gastrointestinal Bleeding in Patients With Severe Ischemic Heart Disease
Status:
Completed
Trial end date:
2011-12-01
Target enrollment:
Participant gender:
Summary
Aspirin and clopidogrel +/- heparin or thrombolytic co-therapy is well established and
effective treatment for unstable cardiac patients. However, the major complication was
gastrointestinal bleeding (GIB) due to peptic ulcer. In the prevention of GIB, anti-ulcer
drug either H2-receptor antagonist (H2RA) and proton pump inhibitor (PPI) were commonly
prescribed. There has been no prospective controlled study to compare the efficacy of these
two classes of anti-ulcer drugs.