Prevention of Frailty With Fisetin and Exercise (PROFFi) in Breast Cancer Survivors
Status:
Recruiting
Trial end date:
2027-10-31
Target enrollment:
Participant gender:
Summary
This phase II trial tests how well fisetin and exercise works in preventing frailty in breast
cancer survivors. Fisetin is a natural substance found in strawberries and other foods and is
available as a nutritional supplement. Nutritional supplements may be useful in eliminating
cells that have undergone a process called senescence. Senescence is when a cell ages and
permanently stops dividing but does not die. Over time, large numbers of these cells build up
in tissues throughout the body and can release harmful substances that cause inflammation and
damage nearby healthy cells. Giving fisetin may eliminate senescent cells in patients with
breast cancer undergoing physical activity.
Phase:
Phase 2
Details
Lead Sponsor:
Jonsson Comprehensive Cancer Center
Collaborators:
National Cancer Institute (NCI) National Institutes of Health (NIH)