Prevention of Dysrhythmias on the Cardiac Intensive Care Unit - Does Maintenance of High-normal Serum Potassium Levels Matter

• Status: Recruiting
• Trial end date: 2023-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether maintaining serum potassium levels at ≥3.6 mEq/L is non-inferior to normal treatment (≥4.5 mEq/L) on the occurrence of new onset atrial fibrillation (AF) dysrhythmia post-surgery in patients undergoing isolated coronary artery bypass graft (CABG) surgery.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Barts & The London NHS Trust
• Collaborator: London School of Hygiene and Tropical Medicine

Criteria

Inclusion Criteria:

• Undergoing isolated CABG surgery

Exclusion Criteria:

• Age <18

• Previous AF

• Ongoing infection/sepsis at the time of recruitment

• Pre-operative high-degree atrioventricular block

• Pre-operative serum K+ >5.5 mEq/L

• Current/previous use of medication for the purposes of cardiac rhythm management

• Dialysis-dependent end-stage renal failure

• Concurrent patient involvement in another clinical trial assessing cardiac rhythm post-operative interventions

• Unable to give informed consent