Prevention of Drug Induced Ototoxicity in Peritoneal Dialysis Patients by N-Acetylcysteine

• Status: Completed
• Trial end date: 2010-05-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether N-acetylcysteine is effective in the prevention of hearing loss in both ears due to aminoglycoside and/or vancomycine induced ototoxicity in peritoneal dialysis patients.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: TC Erciyes University
• Treatments: Acetylcysteine; Amikacin; N-monoacetylcystine

Criteria

Inclusion Criteria:

• End-stage renal disease

• Undergoing continuous ambulatory peritoneal dialysis as a renal replacement therapy

• Clinical diagnosis of a peritonitis episode in a continuous ambulatory peritoneal dialysis patient

• Developing the first continuous ambulatory peritoneal dialysis related peritonitis episode

Exclusion Criteria:

• Being treated with aminoglycoside antibiotics and vancomycine within the previous 3 months

• Detection of mechanical occlusion of external ear

• Having signs of disturbed integrity of tympanic membrane on otoscopy or tympanometry

• History of a continuous ambulatory peritoneal dialysis related peritonitis